Bcl-2 Binding Peptide; Cell-Permeable; Negative Control

Biochem/physiol Actions

Primary TargetA negative control for Cat. No. 197220 (Bcl-2 Binding Peptide, Cell-Permeable).

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable, mutated cpm-1285 peptide analog where Leu¹⁵¹ is replaced by Ala. Does not induce apoptosis and displays about 15 fold lower Bcl-2 binding. Suitable for use as a negative control.

A cell-permeable, mutated cpm-1285 peptide analog (Leu¹⁵¹ replaced by Ala) that does not induce apoptosis and displays nearly 15-fold reduction in Bcl-2 binding. Suitable for use as a negative control for Cat. No. 197220.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wang, J-L., et al. 2000. Cancer Res.60, 1498.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot, flush with an inert gas, and freeze at -20°C. Stock solutions are stable for up to 2 weeks at -20°C.

Sequence

CH₃(CH₂)₈CONH-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Ala-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu-OH

Warning

Toxicity: Standard Handling (A)